ABSTRACT
Background: The COVID-19 has infected more than 140 million people worldwide, killing more than three million people. The existing studies lack research on the relationship between IL-37 and Hs-Troponin markers with COVID-19 syndrome. Thus, the present study aimed to investigate the predictive roles of IL-37 and Hs-Troponin markers in examining patients with COVID-19. Material and Methods: The present study was conducted in Salahalddin General Hospital, Iraq. A total of 45 blood samples were collected from hospitalized COVID-19 patients, and 45 blood samples were collected from healthy people who considered as a control group. Commercial ELISA kits for the quantitative determination of IL-37 (CUSABIO, China) and Hs-Troponin (Abbott, USA) were used. Results: Maximum patients belonged to the age group of 30-39 (33.3%) and 40-49 years (28.9%). Significantly higher levels of IL-37 were found in patients (179.97± 86.12) than in healthy controls (40.29±13.50). Similarly, significantly higher levels of Hs-Troponin were also observed in patients (50.59± 22.19) than in healthy group (15.64± 5.47) (P≤0.05). ROC curve showed that in screening patients with COVID-19, both IL-37 and Hs-Troponin showed 100% sensitivity while specificity was found to be97% and 95% respectively (p<0.05). Moreover, Pearson's correlation test showed a negative correlation between IL-37 and Hs-Troponin. Conclusions: We concluded that the severity of diseases increase with age which might be due to the fact that age progression results in weaker immunity. The increase in age makes people vulnerable to almost all types of infections. In such a situation, any challenging or intense disease can be threatening to one's life. Both IL-37 and Hs-Troponin are good prognostic markers in screening patients with COVID-19. © 2023 Journal of Natural Science, Biology and Medicine.
ABSTRACT
The new emerging coronavirus SARS-CoV2 is an alerting pandemic worldwide. Understanding the epidemiology, viral behavior in the host, and the severity of the disease in an infected patient is a demanding approach for the healthcare system which lead to plan and contemplate the response for further waves of the same virus and even other related viruses. The evaluation of the protection measurements along with analyzing the recorded data of epidemiology and spread provides thorough insights toward the new Coronavirus modes of transmission, infection, and severity. Kurdistan Region of Iraq was hit by the SARS-CoV2 on March 2020 when first confirmed case recorded. The present paper analyzed a full month data of confirmed hospitalized and quarantined cases with regard to age, sex, geographical distribution. The highest risks were shown to be males of their young ages of 30-39 years old in Sulaimani province due to the social structure of the Kurdish population and the geographical position of Sulaimani. Social integration played a significant role in the spreading the virus in all cities of Kurdistan first onset of the virus in the community. Diagnosed hospitalized cases were mostly suffered from high fever, dry cough and breathing difficulties. The mortality rate was shown to be reasonable, and the majority of the cases were recovered after hospitalization and receive supportive treatment. Social distancing and total lockdown played a significant role in viral spread containment. The health authorities prevented devastating outbreak through tracing all the cases and their contacts, isolating the suspicious contacts, quarantining the neighborhoods were the virus found. Further investigation is needed in a larger scale of data in order to be armed with adequate knowledge for any other waves of COVID-19 in the region.Copyright © 2020 Ubiquity Press. All rights reserved.